Research Training Group 1459
Sorting and Interactions between Proteins of Subcellular Compartments

Please note that the PhD program of the Research Training Group 1459 ended in April 2017 after 9 years of funding.
This website serves documentary reasons. Updates are being made for list of GRK1459 publications only.

The Research Training Group 1459 was funded by the DFG (German Research Foundation) from May 2008 until April 2017.

The Research Training Group 1459 was formed by scientists from the University Medical Center Hamburg-Eppendorf, the Institute of Biochemistry at the University Kiel and the Bernhard-Nocht-Institute for Tropical Medicine in Hamburg. Its program was open to students with a diploma/master in natural sciences and to medical students. The general topic of the RTG was sorting and transport of selected proteins within the Golgi apparatus and endosomal compartments. In these organelles the decision is made whether a newly synthesized protein reaches its target via the secretory/biosynthetic pathway, or a recently internalized molecule (or bacterium) reaches its intracellular destination via the endocytic/phagocytic pathway. Missorted proteins may lead to loss of function in their target organelles affecting the well being of the cell and the organism as a whole. By focussing on selected model proteins, basic mechanisms of the biogenesis of intracellular compartments as well as the balance of membrane transport between organelles and the interplay between cytosolic and membrane proteins were investigated. The majority of projects addressed sorting and transport processes under pathological conditions in cells derived from patients or mouse models of human diseases or cells infected by bacteria or in parasite cells.

Students went through a three year curriculum of academic as well as non-academic courses in molecular and cellular biology, biochemistry, infectiology, microbiology, and molecular biomedicine. The Research Training Group offered a continuous educational program with lectures, practical courses, seminars given by leading national and international scientists, regular report meetings and an international symposium every second year. Each student had the opportunuity to spend 1-3 months abroad in a laboratory cooperating in the research field. The program provided a broad education, not just on the specific topic of the thesis, but also in research topics of the other participating groups. Active participitation and engagement of the students in the design of this curriculum strengthened their scientific independence and international competitiveness.

The scientific program of the Research Training Group 1459 was embedded in research interests of Collaborative Research Center 877 “Proteolysis as a Regulatory Event in Pathophysiology”