Regulation of lipoprotein uptake into liver and brown adipose tissue
Prof. Dr. Jörg Heeren (2008 – 2017)
University Medical Center Hamburg-Eppendorf, Department of Biochemistry and Molecular Cell Biology
Abnormalities in lipid and lipoprotein metabolism are associated with the development of atherosclerosis and the metabolic syndrome. The uptake and intracellular processing of lipoproteins into liver and brown adipose tissue directly influence plasma lipoprotein levels. These processes are mediated by lipoprotein receptors such as CD36, LDL receptor and the LDL receptor-related protein 1 (LRP1) in dependence on intracellular adaptor proteins. In this project we want to investigate how lipoprotein receptor function and lipid uptake processes are regulated with the focus on endosomal trafficking in hepatocytes and brown adipocytes.