Project 4

Project 4

Exosomal transports of prions

Project leader:
Prof. Dr. Markus Glatzel (2008 – 2017)
University Medical Center Hamburg-Eppendorf, Institute of Neuropathology


Prion diseases are fatal neurodegenerative disorders which are transmissible. An essential part of the infectious agent, termed the prion, is composed of an abnormal isoform of the host-encoded cellular prion-protein termed PrPSc. The molecular details underlying PrPSc formation and the mechanisms involved in the spread of infectious prions within affected hosts and from donor to host are poorly understood. Recently, exosomes have been shown to mobilize PrPSc as well as prion infectivity. Moreover retroviral infection increases exosome formation and virions have been shown to contain PrPSc. The project focus on the investigation of the role of exosomes in secretion of cellular- and disease-associated forms of the prion protein