Publications

Publications

(GRK1459 members marked with *)

2020

[122] A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites. Birnbaum J, Scharf S, Schmidt S, Jonscher E*, Hoeijmakers WAM, Flemming S*, Toenhake CG, Schmitt M, Sabitzki R, Bergmann B, Fröhlke U, Mesén-Ramírez P, Blancke Soares A*, Herrmann H, Bártfai R, Spielmann T* (2020) Science 367: 51-59. Abstract

2019

[121] Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Heybrock S * , Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M * , Heeren J * , Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P * , Neculai D (2019) Nat Commun 10:3521. Abstract

[120] PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles. Fischer AW*, Albers K*, Schlein C, Sass F, Krott LM*, Schmale H, Gordts PLSM, Scheja L, Heeren J* (2019) Biochim Biophys Acta Mol Basis Dis 1865: 1592-603. Abstract

[119] Activation of the macroautophagy pathway by Yersinia enterocolitica promotes intracellular multiplication and egress of yersiniae from epithelial cells. Valencia Lopez MJ*, Schimmeck H, Gropengießer J, Middendorf L, Quitmann M, Schneider C, Holstermann B, Wacker R, Heussler V, Reimer R, Aepfelbacher M*, Ruckdeschel K (2019) Cell Microbiol 17: e13046. Abstract

[118] SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9. Klose M*, Salloum JE, Gonschior H, Linder S* (2019) J Cell Biol pii: jcb.201812106. Abstract

[117] PfVPS45 is required for host cell cytosol uptake by malaria blood stage parasites. Jonscher E*, Flemming S*, Schmitt M, Sabitzki R, Reichard N, Birnbaum J, Bergmann B, Höhn K, Spielmann T* (2019) Cell Host Microbe 25: 166-73. Abstract

[116] A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. von Kleist⁠ L⁠, ⁠ Ariunbat⁠ K*⁠, Braren⁠c I, Stauber⁠ T, Storch⁠ S*, Danyukova⁠ T⁠ (2019) Mol Genet Metab 126: 196-205. Abstract

2018

[115] PLD3 and spinocerebellar ataxia. Gonzalez AC*, Stroobants S, Reisdorf P, Gavin AL, Nemazee D, Schwudke D, D’Hooge R, Saftig P*, Damme M (2018) Brain 141: e78.

[114] Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity. Schmiesing J, Storch S*, Dörfler AC*, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T* (2018) Cell Rep 24: 2946-56. Abstract

[113] Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. Heine M, Fischer AW*, Schlein C, Jung C, Straub LG, Gottschling K, Mangels N*, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J* (2018) Cell Metab pii: S1550-4131(18)30402-9. Abstract

[112] Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Jayson CBK, Arlt H, Fischer AW*, Lai ZW, Farese RV, Walther TC (2018) Mol Biol Cell 29: 2045-54. Abstract

[111] The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins. Fischer AW#*, Albers K#*, Krott LM*, Hoffzimmer B*, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J* (2018) Mol Metab 16: 88-99. Abstract (#equal contributation)

[110] Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells. Di Lorenzo G*, Voltolini Velho R, Winter D, Thelen M, Ahmadi S, Schweizer M, De Pace R*, Cornils K, Yorgan TA, Grüb S, Hermans-Borgmeyer I, Schinke T, Müller-Loennies S, Braulke T*, Pohl S*(2018) Mol Cell Proteomics 17: 1612-26. Abstract

[109] Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes. Maxson ME, Naj X*, O’Meara TR, Plumb JD, Cowen LE, Grinstein S (2018) Elife 7: e34798. Abstract

[108] Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, Ariunbat K*, Thelen M, Brocke-Ahmadinejad N, Mole SE, Storch S* (2018) Hum Mol Genet 27: 1711-22. Abstract

[107] Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling. Bartelt A*, Behler-Janbeck F, Beil FT, Koehne T, Müller B*, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J*, Niemeier A (2018) Bone Res 6: 4 Abstract

2017

[106] Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies. Conrad KS, Cheng TW, Ysselstein D, Heybrock S*, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M*, Saftig P*, Liu S, Qiu X, Ehlers MD (2017) Nat Commun 8: 1908 Abstract

[105] Disease-causing mutations affecting surface residues of mitochondrial glutaryl-CoA dehydrogenase impair stability, heteromeric complex formation and mitochondria architecture. Schmiesing J, Lohmöller B*, Schweizer M, Tidow H, Gersting SW, Muntau AC, Braulke T*, Mühlhausen C (2017) Hum Mol Genet 26: 538-51 Abstract

[104] Diverse functions of the prion protein – Does proteolytic processing hold the key? (Review) Linsenmeier L, Altmeppen HC, Wetzel S, Mohammadi B*, Saftig P*, Glatzel M* (2017) Biochim Biophys Acta 1864: 2128-37 Abstract

[103] Functional assays for the assessment of the pathogenicity of variants in GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies. Völker JM*, Dergai M, Abriata LA, Mingard Y, Ysselstein D, Krainc D, Dal Peraro M, von Mollard GF, Fasshauer D, Koliwer J*, Schwake M* (2017) Dis Model Mech pii: dmm.029132. doi: 10.1242/dmm.029132. Abstract

[102] Site-1 protease and lysosomal homeostasis. (Review) Velho RV, De Pace R*, Klünder S*, Di Lorenzo G*, Schweizer M, Braulke T*, Pohl S* (2017) Biochim Biophys Acta pii: S0167-4889(17)30186-6 Abstract

[101] SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V*, Nia FH, Beifuss M*, Boeckers T, Kreienkamp HJ*, Barsukov IL, Ivaska J (2017) Nat Cell Biol 19:292-305 Abstract

[100] A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S*, Reichard N, Soares AB*, Mesén-Ramírez P, Jonscher E*, Bergmann B, Spielmann T* (2017) Nat Methods 14:450-6 Abstract

[99] Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale. Golldack A, Henke B, Bergmann B, Wiechert M, Erler H, Blancke Soares A*, Spielmann T*, Beitz E (2017) PLoS Pathog 13:e1006172 Abstract

[98] Progress in imaging methods: insights gained into Plasmodium biology. (Review) De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T*, Frischknecht F, Heussler VT (2017) Nat Rev Microbiol 15:37-54 Abstract

[97] Acting on Actin: Rac and Rho Played by Yersinia. (Review) Aepfelbacher M*, Wolters M (2017) Curr Top Microbiol Immunol 399:201-220 Abstract

[96] Disruption of the v-H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Kissing S*, Rudnik S*, Damme M, Lüllmann-Rauch R, Ichihara A,  Kornak U, Eskelinen EL, Jabs S, Heeren J*, De Brabander J, Haas A, Saftig P* (2017) Autophagy 13:670-85 Abstract

[95] Quantitative proteome analysis of mouse liver lysosomes provides evidence for mannose 6-phosphate-independent targeting mechanisms of acid hydrolases in mucolipidosis II. Markmann S#*, Krambeck S#*, Hughes CJ, Mirzaian M, Aerts JM, Saftig P*, Schweizer M, Vissers JC, Braulke T*, Damme M (2017) Mol Cell Proteomics 16:438-450 Abstract (#equal contributation)

2016

[94] Identification of the interaction domains between α- and γ-subunits of GlcNAc-1-phosphotransferase. Velho RV, De Pace R*, Tidow H, Braulke T*, Pohl S* (2016) FEBS Lett 23: 4287-95 Abstract

[93] Parkinson’s disease: acid-glucocerebrosidase activity and alpha-synuclein clearance. (Review) Blanz J*, Saftig P* (2016) J Neurochem 139 Suppl 1: 198-215. Abstract

[92] Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. Brill MS#, Kleele T#, Ruschkies L*#, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M*, Misgeld T (2016) Neuron 92:845-56 Abstract (#joint first authors)

[91] Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation. Krott LM*, Piscitelli F, Heine M, Borrino S, Scheja L, Silvestri C, Heeren J*, Di Marzo V (2016) J Lipid Res 57: 464-73 Abstract

[90] Retinal Degeneration in Mice Deficient in the Lysosomal Membrane Protein CLN7. Jankowiak W, Brandenstein L*, Dulz S, Hagel C, Storch S*, Bartsch U (2016) Invest Ophthalmol Vis Sci 57: 4989-98 Abstract

[89] Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells. Rauch L*, Hennings K, Trasak C, Röder A*, Schröder B, Koch-Nolte F, Rivera-Molina F, Toomre D, Aepfelbacher M* (2016) J Cell Sci 129: 2937-49 Abstract

[88] Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells. Berneking L*, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M* (2016) PLoS Pathog 12: e1005660 Abstract

[87] Actin regulation during phagocytosis of Borrelia burgdorferi by macrophages. Naj X*, Linder S* (2016) Curr Top Microbiol Immunol Abstract

[86] The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites. De Niz M, Ullrich AK, Heiber A, Blancke Soares A*, Pick C, Lyck R, Keller D, Kaiser G, Prado M, Flemming S*, Del Portillo H, Janse CJ, Heussler V, Spielmann T* (2016) Nat Commun 7: 11659 Abstract

[85] Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity. Mesén-Ramírez P, Reinsch F*, Blancke Soares A*, Bergmann B, Ullrich AK, Tenzer S, Spielmann T* (2016) PLoS Pathog 12: e1005618 Abstract

[84] Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding. Boddey JA, O’Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S*, Spielmann T*, Przyborski J, Babon JJ, Cowman AF (2016) Nat Commun 7: 10470 Abstract

[83] Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2. Zunke F*, Andresen L, Wesseler S*,  Groth J*, Arnold P, Rothaug M*, Mazzullic JR, Krainc D, Blanz J*, Saftig P*, Schwake M* (2016) Proc Natl Acad Sci U S A doi:10.1073/pnas.1514005113 Abstract

[82] Lysosomal dysfunction and impaired autophagy in a novel mouse model deficient for the lysosomal membrane protein Cln7. Brandenstein L*, Schweizer M, Sedlacik J, Fiehler J, Storch S* (2016) Hum Mol Genet 25: 777-91 Abstract

[81] Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites. Prinz B, Harvey KL, Wilcke L, Ruch U*, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T*, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW* (2016)  Sci Rep 6: 34479 Abstract

[80] Exosomal PrP(C) drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity. Falker C*, Hartmann A, Guett I*, Dohler F, Altmeppen H, Betzel C, Schubert R, Thurm D*, Wegwitz F, Joshi P, Verderio C, Krasemann S, Glatzel M* (2016) J Neurochem 137: 88-100 Abstract

2015

[79] αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor. Kortüm F*, Harms FL, Hennighausen N, Rosenberger G (2015) PLoS One 10: e0132737 Abstract

[78] Vacuolar ATPase in phagosome-lysosome fusion. Kissing S*, Hermsen C, Repnik U, Nesset CK, von Bargen K, Griffiths G, Ichihara A, Lee BS, Schwake M*, De Brabander J, Haas A, Saftig P* (2015) J Biol Chem 290: 14166-80. Abstract

[77] Critical Steps in Protein Export of Plasmodium falciparum Blood Stages. (Review) Spielmann T*, Gilberger TW* (2015) Trends Parasitol 31: 514-25. Abstract

[76] Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice. Damme M, Stroobants S, Lüdemann M, Rothaug M*, Lüllmann-Rauch R, Beck HC, Ericsson A, Andersson C, Fogh J, D’Hooge R, Saftig P*, Blanz J* (2015) Ann Clin Transl Neurol 2: 987-1001. Abstract

[75] LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease. Rothaug M*, Stroobants S, Schweizer M, Peters J*, Zunke F*, Allerding M, D’Hooge R, Saftig P*, Blanz J* (2015) Acta Neuropathol Commun 3: 6 Abstract

[74] Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease. Peters J*, Rittger A, Weisner R, Knabbe J*, Zunke F*, Rothaug M*, Damme M, Berkovic SF, Blanz J*, Saftig P*, Schwake M* (2015) Biochem Biophys Res Commun 457: 334-40 Abstract

[73] Subunit interactions of the disease-related hexameric GlcNAc-1-phosphotransferase complex. De Pace R*, Velho RV, Encarnação M*, Marschner K*, Braulke T*, Pohl S* (2015) Hum Mol Genet 24: 6826-35 Abstract

[72] Shedding light on prion disease. (Review) Glatzel M*, Linsenmeier L, Dohler F, Krasemann S, Puig B, Altmeppen HC (2015) Prion 9: 244–56 Abstract

[71] ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages. Naj X*, Linder S* (2015) Cell Rep 12: 1-15 Abstract

[70] Mannose 6-phosphate-independent lysosomal sorting of LIMP-2. Blanz J*, Zunke F*, Markmann S*, Damme M, Braulke T*, Saftig P*, Schwake M* (2015) Traffic 16: 1127-36  Abstract

[69] Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control. Klünder S*, Heeren J*, Markmann S*, Santer R, Braulke T*, Pohl S* (2015) J Lipid Res 56: 1625-32 Abstract

[68] Identity of a Plasmodium lactate/Hþ symporter structurally unrelated to human transporters. Wu B, Rambow J, Bock S, Holm-Bertelsen J, Wiechert M, Blancke Soares A*, Spielmann T*, Beitz E (2015) Nat Comm 6: 6284 Abstract

[67] Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity. Wagner T, Bartelt A*, Schlein C*, Heeren J* (2015) PLoS One 10: e0145102 Abstract

[66] Analyses of disease-related GNPTAB mutations define a novel GlcNAc-1-phosphotransferase interaction domain and an alternative site-1 protease cleavage site. Velho RV, De Pace R*, Klünder S*, Sperb-Ludwig F, Lourenço CM, Schwartz IV, Braulke T*, Pohl S* (2015) Hum Mol Genet 24: 3497-505 Abstract

[65] Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes. Lasrich D*, Bartelt A*, Grewal T, Heeren J* (2015) Exp Cell Res 337: 94-102 Abstract

[64] Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting. Markmann S*, Thelen M, Cornils K, Schweizer M, Brocke-Ahmadinejad N, Willnow T, Heeren J*, Gieselmann V, Braulke T*, Kollmann K (2015) Traffic 16: 743-59 Abstract

[63] The Golgi-associated PDZ domain protein PIST/GOPC stabilizes the
β1-adrenergic receptor in intracellular compartments after internalization.
Koliwer J*, Park M, Bauch C*, von Zastrow M, Kreienkamp HJ* (2015) J Biol Chem 290: 6120-9 Abstract

[62] Biosynthesis, targeting, and processing of lysosomal proteins: Pulse-chase labeling and immune precipitation. Pohl S*, Hasilik A (2015) Methods Cell Biol 126: 63-83  Abstract

2014

[61] Autophagy in neuronal cells: general principles and physiological and pathological functions. (Review) Damme M, Suntio T, Saftig P*, Eskelinen EL (2014) Acta Neuropathol 129: 337-62  Abstract

[60] LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance. Rothaug M*, Zunke F*, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann, Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M*, Saftig P*, Krainc D, Schwake M*, Blanz J* (2014) Proc Natl Acad Sci U S A 111: 15573-8  Abstract

[59] The GPI-anchoring of PrP: implications in sorting and pathogenesis. (Review) Puig B, Altmeppen H, Glatzel M* (2014) Prion 8: 11-8  Abstract

[58] Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins. Bauch C*, Koliwer J*, Buck F, Hönck HH, Kreienkamp HJ* (2014) PLoS One 9: e88529  Abstract

[57] A role for exocyst in maturation and bactericidal function of staphylococci-containing endothelial cell phagosomes. Rauch L*, Hennings K, Aepfelbacher M* (2014) Traffic 15: 1083-98  Abstract

[56] Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages. Hoffmann AK, Naj X*, Linder S* (2014) FASEB J 28: 3075-89 Abstract

[55] GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites. Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L*, Schroeder M, Schweizer M, Kneussel M* (2014) Proc Natl Acad Sci U S A 111: 5030-5 Abstract

[54] Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant.
Albers K*, Schlein C*, Wenner K, Lohse P, Bartelt A*, Heeren J*, Santer R, Merkel M (2014) Atherosclerosis 233: 97-103 Abstract

[53] The lectin OS-9 delivers mutant neuroserpin to endoplasmic reticulum associated degradation in familial encephalopathy with neuroserpin inclusion bodies. Schipanski A*#, Oberhauser F*#, Neumann M, Lange S, Szalay B, Krasemann S, van Leeuwen FW, Galliciotti G, Glatzel M* (2014) Neurobiol Aging 35: 2394-403 Abstract (#joint first authors)

[52] Mucolipidosis II-Related Mutations Inhibit the Exit from the Endoplasmic Reticulum and Proteolytic Cleavage of GlcNAc-1-Phosphotransferase Precursor Protein (GNPTAB). De Pace R*, Coutinho MF, Koch-Nolte F, Haag F, Prata MJ, Alves S, Braulke T*, Pohl S* (2014) Hum Mutat 35: 368-76  Abstract

[51] Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease. Damme M, Brandenstein L*, Fehr S, Jankowiak W, Bartsch U, Schweizer M, Hermans- Borgmeyer I, Storch S* (2014) Neurobiol Dis 65C: 12-24 Abstract

2013

[50] The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication. Finsel I, Ragaz C, Hoffmann C, Harrison CF, Weber S, van Rahden VA*, Johannes L, Hilbi H (2013) Cell Host Microbe 14: 38-50. Abstract

[49] The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. Kraft S, Jouvin MH, Kulkarni N, Kissing S*, Morgan ES, Dvorak AM, Schröder B, Saftig P*, Kinet JP (2013) J Immunol 191: 2871-8. Abstract

[48] Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles. Schmid J, Oelbe M*, Saftig P*, Schwake M*, Schweda F (2013) Pflugers Arch 465: 895-905. Abstract

[47] Amyloid-precursor-protein-lowering small molecules for disease modifying therapy of Alzheimer’s disease. Rosenkranz SC*, Geissen M, Härter K*, Szalay B, Ferrer I, Vogel J*, Smith S, Glatzel M* (2013) PLoS One 8: e82255. Abstract

[46] A novel interaction between aging and ER overload in a protein conformational dementia. Schipanski A*, Lange S, Segref A, Gutschmidt A, Lomas DA, Miranda E, Schweizer M, Hoppe T, Glatzel M* (2013) Genetics 193: 865-76. Abstract

[45] Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics (Review). Kneussel M*, Wagner W (2013) Nat Rev Neurosci 14: 233-47 Abstract

[44] Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, Pick C, Grüring C, Flemming S*, Oberli A, Schoeler H, Retzlaff S, Mesén-Ramírez P, Hiss JA, Kadekoppala M, Hecht L, Holder AA, Gilberger TW*, Spielmann T* (2013) PLoS Pathog 9: e1003546 Abstract

[43] Protein export in malaria parasites: many membranes to cross. (Review) Marti M, Spielmann T* (2013) Curr Opin Microbiol 16: 445-51  Abstract

[42] Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Neculai D, Schwake M*, Ravichandran M, Zunke F*, Collins RF, Peters J*, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P*, Grinstein S, Dhe-Paganon S (2013) Nature 504: 172-6  Abstract

[41] Lysosomal membrane proteins and their central role in physiology. (Review) Schwake M*, Schröder B, Saftig P* (2013) Traffic 14:739-48  Abstract

[40] Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II. Kollmann K, Pestka JM, Kühn SC, Schöne E*, Schweizer M, Karkmann K*, Otomo T, Catala-Lehnen P, Failla AV, Marshall RP, Krause M, Santer R, Amling M, Braulke T*, Schinke T (2013) EMBO Mol Med 5: 1871-86 Abstract

[39] Ultrastructural analysis of neuronal and non-neuronal lysosomal storage in mucolipidosis type II knock-in mice. Schweizer M, Markmann S*, Braulke T*, Kollmann K Ultrastruct Pathol (2013) 37: 366-72  Abstract

[38] Plasmodium falciparum Atg8 implicated in both autophagy and apicoplast formation. Tomlins A, Ben-Rached F, Williams R, Proto W, Coppens I, Ruch U*, Gilberger TW*, Coombs G, Mottram J, Müller M, Gordon Langsley G (2013) Autophagy 9: 1540-52 Abstract

[37] Transport of the GlcNAc-1-phosphotransferase α/β-subunit precursor protein to the Golgi apparatus requires a combinatorial sorting motif. Franke M*, Braulke T*, Storch S* (2013) J Biol Chem 288: 1238-49 Abstract

[36] Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration. Altmeppen HC, Prox J, Puig B, Dohler F, Falker C*, Krasemann S, Glatzel M* (2013) FEBS J 280: 4338-47  Abstract

2012

[35] Uncovering common principles in protein export of malaria parasites. Grüring C, Heiber A, Kruse F, Flemming S*, Franci G, Colombo SF, Fasana E, Schoeler H, Borgese N, Stunnenberg HG, Przyborski JM, Gilberger TW*, Spielmann T* (2012) Cell Host Microbe 12: 717-29 Abstract

[34] Lysosomal dysfunction causes neurodegeneration in mucolipidosis II ‚knock-in‘ mice. Kollmann K, Damme M, Markmann S*, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK*, Pohl S*, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T* (2012) Brain 135: 2661-75 Abstract

[33] The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module. van Rahden VA*, Brand K*, Najm J, Heeren J*, Pfeffer SR, Braulke T*, Kutsche K* (2012) Hum Mol Genet 21: 5019-38 Abstract

[32] Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. Gordts PL, Bartelt A*, Nilsson SK, Annaert W, Christoffersen C, Nielsen LB, Heeren J*, Roebroek AJ (2012) PLoS One 7: e38330 Abstract

[31] Proteolytic processing of the prion protein in health and disease (Review). Altmeppen HC, Puig B, Dohler F, Thurm DK*, Falker C*, Krasemann S, Glatzel M* (2012) Am J Neurodegener Dis 1: 15-31 Abstract

[30] Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7 Steenhuis P*, Froemming J, Reinheckel T, Storch S* (2012) Biochim Biophys Acta 1822: 1617-28 Abstract

[29] Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite. Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U*, Heussler V, Spielmann T*, Parkinson J, Gilberger TW* (2012) Mol Biol Evol 29: 2113-32 Abstract

[28] A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand beta-glucocerebrosidase. Zachos C*, Blanz J*, Saftig P*, Schwake M* (2012) Traffic 13: 1113-23 Abstract

[27] A new, powerful player in lipoprotein metabolism: brown adipose tissue (Review). Bartelt A*, Merkel M, Heeren J* (2012) J Mol Med 90: 887-93 Abstract

[26] Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. Laatsch A, Panteli M, Sornsakrin M, Hoffzimmer B*, Grewal T, Heeren J* (2012) PLoS ONE 7: e29385  Abstract

[25] Regional and subcellular distribution of the receptor-targeting protein PIST/GOPC in the rat central nervous system. Chen A#, Gössling E#*, Witkowski L, Bhindi A, Bauch C*, Roussy G, Sarret P, Kreienkamp HJ*, Stroh T (2012) J Comp Neurol 520: 889-913 #contributed equally Abstract

[24] The role of apolipoprotein E in bone metabolism (Review). Niemeier A, Schinke T, Heeren J*, Amling M (2012) Bone 50: 518-24 Abstract

2011

[23] A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Marschner K*, Kollmann K, Schweizer M, Braulke T*, Pohl S* (2011) Science 333: 87-90 Abstract

[22] Brown adipose tissue activity controls triglyceride clearance. Bartelt A*, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J* (2011) Nat Med 17: 200-5  Abstract

[21] Posttranslational modifications of the gamma-subunit affect intracellular trafficking and complex assembly of the GlcNAc-1-phosphotransferase. Encarnação M*, Kollmann K, Trusch M, Braulke T*, Pohl S* (2011) J Biol Chem 286: 5311-18 Abstract

[20] Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo. Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D*, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P*, Glatzel M* (2011) Mol Neurodegener 6: 36 Abstract

[19] Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. Kokkola T, Kruse C, Roy-Pogodzik EM, Pekkinen J, Bauch C*, Hönck HH, Hennemann H, Kreienkamp HJ* (2011) FEBS Lett 585: 2665-70 Abstract

[18] Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers. Behnke J, Eskelinen EL, Saftig P*, Schröder B (2011) Biochem J 434: 219-31  Abstract

[17] The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis. Kortüm F*, Das S, Flindt M, Morris-Rosendahl DJ, Stefanova I, Goldstein A, Horn D, Klopocki E, Kluger G, Martin P, Rauch A, Roumer A, Saitta S, Walsh LE, Wieczorek D, Uyanik G, Kutsche K*, Dobyns WB (2011) J Med Genet 48: 396-406 Abstract

[16] Altered endocannabinoid signalling after a high-fat diet in Apoe (-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance. Bartelt A*, Orlando P, Mele C, Ligresti A, Toedter K, Scheja L, Heeren J*, Di Marzo V (2011) Diabetologia 54: 2900-10  Abstract

[15] N-glycans and Glycosylphosphatidylinositol-Anchor Act on Polarized Sorting of Mouse PrPC in Madin-Darby Canine Kidney Cells. Puig B, Altmeppen HC, Thurm D*, Geissen M, Conrad C, Braulke T*, Glatzel M* (2011). PLoS ONE 6: e24624 Abstract

[14] Apolipoprotein A-V; a potent triglyceride reducer. (Review) Nilsson SK, Heeren J*, Olivecrona G, Merkel M (2011) Atherosclerosis 219: 15-21 Abstract

2010

[13] Loss of N-acetylglucosamine-1-phosphotransferase gamma subunit due to intronic mutation in GNPTG causes mucolipidosis type III gamma: Implications for molecular and cellular diagnostics. Pohl S*, Encarnacão M*, Castrichini M, Müller-Loennies S, Muschol N, Braulke T* (2010) Am J Med Genet A 152A: 124-32 Abstract

[12] Lysosomal targeting of the CLN7 membrane glycoprotein and transport via the plasma membrane require a dileucine motif. Steenhuis P*, Herder S, Gelis S, Braulke T*, Storch S* (2010) Traffic 11: 987-1000 Abstract

[11] Mannose 6-phosphorylation in health and disease (Review). Kollmann K, Pohl S*, Marschner K*, Encarnação M*, Sakwa I, Tiede S, Poorthuis BJ, Lübke T, Müller-Loennies S, Storch S*, Braulke T* (2010) Eur J Cell Biol 89: 117-23 Abstract

[10] Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages. Pohl S*, Tiede S, Marschner K*, Encarnação M*, Castrichini M, Kollmann K, Muschol N, Ullrich K, Müller-Loennies S, Braulke T* (2010) J Biol Chem 285: 23936-44 Abstract

[09] Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase. Blanz J*, Groth J*, Zachos C*, Wehling C, Saftig P*, Schwake M* (2010) Hum Mol Genet 19: 563-72 Abstract

[08] Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity. Bartelt A*, Beil FT, Schinke T, Roeser K, Ruether W, Heeren J*, Niemeier A (2010) Bone 47: 736-45 Abstract

[07] The proteome of lysosomes (Review). Schröder BA, Wrocklage C, Hasilik A, Saftig P* (2010) Proteomics 10: 4053-76 Abstract

[06] Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways? (Review) Spielmann T*, Gilberger TW*(2010) Trends Parasitol 26: 6-10 Abstract

2009

[05] Sorting of lysosomal proteins (Review). Braulke T*, Bonifacino JS (2009) Biochim Biophys Acta 1793: 605-14 Abstract

[04] Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (Review). Saftig P*, Klumperman J (2009) Nat Rev Mol Cell Biol 10: 623-35 Abstract

[03] Yersinia enterocolitica differentially modulates RhoG activity in host cells. Roppenser B, Röder A*, Hentschke M, Ruckdeschel K, Aepfelbacher M* (2009) J Cell Sci 122: 696-705 Abstract

[02] Sequence requirements for the export of the Plasmodium falciparum Maurer’s clefts protein REX2. Haase S, Herrmann S, Grüring C, Heiber A, Jansen PW, Langer C, Treeck M, Cabrera A, Bruns C, Struck NS, Kono M, Engelberg K, Ruch U*, Stunnenberg HG, Gilberger TW*, Spielmann T* (2009) Mol Microbiol 71: 1003-17 Abstract

[01] Glycosylation- and phosphorylation-dependent intracellular transport of lysosomal hydrolases (Review). Pohl S*, Marschner K*, Storch S*, Braulke T*(2009) Biol Chem 390: 521-27 Abstract